Which anti-virus do you use? Personally, I use symantecs. It takes care of most of the trouble. If it doesn't then I have to use Hijack, but I hate doing manual work for that.
I only check it now and then every 3 months, I usually don't get viruses unless I go to some LAN parties with kids full of viruses in their comps. Some dodgy downloads that I have to do for cracks gets me in trouble too sometimes.
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