Infected plz help

I was infected with either a virus or spyware earlier today. I was able to use system restore to get to where I am functioning again but I do not believe all is well. I ran adaware, Norton and spybot. Spybot had some artifacts that it could not remove. Norton found two entries. I have yet to reboot for fear that the malware will reappear. I need desperate help. Thanks in advance for any help.