mouse problems

i dont know if this would come under softwear or hardwear problems but im gona mention it anyway. basically my mouse keeps crashing when using computer, mainly whilst gaming. when it crashes the cursor will stay where it was last, but i can still click on icons and other stuff on screen. so basically i can still select things but cant see what im clicking on as cursor is stuck in middle of screen. iv tried avg anti-virus and anti-spyware scans and got rid of evrything wrong there and iv also bought a new mouse as i was told that it was possibly the mouse at fault but the problem still persists. i tried a disk cleanup earlier so i dont know if that will sort the problem but i thought i would post this anyway.
any ideas of how the problem came about and how to fix it would be appreciated.
thx